Abstract
Keap1 is a pluripotent protein which plays a predominant role in cellular homeostasis and stress responses. Given that the cellular environment is quite dynamic and versatile, further investigation of the function of Keap1 depends on tools for specific and real-time detection of Keap1. Herein, we report the development of functional affinity-based small-molecule probes which can overcome some shortcomings of current methods and be applied in further studying the function of Keap1.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Cell Line
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Dose-Response Relationship, Drug
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Drug Design*
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Fluorescent Dyes / chemistry*
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Fluorescent Dyes / pharmacology
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Humans
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Kelch-Like ECH-Associated Protein 1 / analysis*
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Kelch-Like ECH-Associated Protein 1 / antagonists & inhibitors
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Molecular Structure
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Small Molecule Libraries / chemistry*
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Small Molecule Libraries / pharmacology
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Structure-Activity Relationship
Substances
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Fluorescent Dyes
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KEAP1 protein, human
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Kelch-Like ECH-Associated Protein 1
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Small Molecule Libraries